Could there potentially be novel categories of drugs that work on receptors...
So far we are familiar with many different types of drugs. Here is a few example of what I mean: GABAergics/Depressants (alcohol, benzos, barbiturates, Gabapentinoids) working on the GABA receptor (and...
View ArticleKratom Hot-almost boil water question?
So Kratom Powder like I'm not sure about potency alkaloid-wise, well I'm sure I do not know almost nothing exept that it is green malay or Maeng da or sorry White Borneo. Thing is making coffee is and...
View ArticleWhy is it said that modafinil isn't soluble ?
It says everywhere that modafinil is virtually insoluble in anything ingestible. But this patent (https://patents.google.com/patent/US6919378B2/en) says: "...A mixture of 95 mL of PEG-400 and 5 ml of...
View ArticleEverything you ever wanted to know about opiate receptors
The book "The Opiate Receptors 2nd edition" by Gavril W. Pasternak covers the latest knowledge on opiate receptors and related receptor subtypes. It discusses many topics pertaining to the unique...
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Has anyone tried the heroin purification techniques?
Greetings! I'm somewhat new to the forums, or at least to posting. I've been cruising these forums for longer than I can remember, as this is an incredible source for information. I ran into an issue I...
View ArticleH4CBD - not just hydrogenated? Not isomerizable through missing atom?
I've been thinking about what would happen if you tried to isomerize H4-CBD the way you would regular CBD. One would expect to simply obtain HHC and various variants thereof, depending on the reaction...
View ArticleThe History of Fentanyl
https://www.jpain.org/article/S1526-5900(14)00905-5/pdf Note that before fentanyl, phenoperidine was used in surgery. Unfortunately phenoperidine demonstrates how the ACTUAL potency of 'high potency'...
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Chemistry and toxicity of krokodil
1 hosted at ImgBB Image 1 hosted in ImgBB ibb.co It was not possible to show EVERY intermediate but I have shown the five major points of the scaffolds that undergo modification .i.e. 1 -...
View ArticleDopamine Receptors And Their Behavioural Affects
Apologies if there’s already a thread discussing this, I am blind and using my phone to access the Internet, so I easily miss things. Since dopamine modulates so many behaviours including but not...
View ArticleUseful neuroscience/pharmacology threads
Neuroanatomy and the Brain Erowid/BlueLight Neuropharmacology Text List of FREE Chemistry Databases BEST Websites to Self-Educate Psycho-Pharmacology?? The Big & Bangin' Miscellaneous...
View ArticleI have a theory of Why 'Opiate Rage' exists.
Ok, so I know the common explanation of why opiate rage exists is because there are some receptors that opiates work on/activate, and this does certain interaction with other part of the brain, bla bla...
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tropa-cocaine
Apparantly this is a potent cocaine analogue. Couldn't really find much about this, and nothing at all on bluelight(!?). Anyone tried it? any good?
View ArticleWhy aren't gelatine capsules used for IR formulations?
Wouldn't a gelatine capsule hit you faster than a pressed pill? I'd imagine when it comes to QOA (quick onset anxiety) or pain spikes, a benzo or opioid coming up even a couple minutes faster can make...
View ArticleThe science behind cannabis cessation and vivid dreams
I took a break from weed over the summer for mental health reasons but eventually I fell off the wagon in October and started getting high on the daily again. Anyways during my breaks I've noticed my...
View ArticleNew Dawn Breaks - The XenoGPCR, a new conceptual paradigm for psychonautic...
Hello all, I have been working with DREADDs recently. DREADD is an acronym for Designer Receptor Exclusively Activated by a Designer Drug. These are synthetic GPCRs that do not occur in nature that...
View ArticleUnlocking the Brain: The Latest in Neuroscience and Pharmacology
Hello Neuroscience and Pharmacology Enthusiasts, I’m Serhat, and I'd like to welcome you to a stimulating discussion on the latest developments and breakthroughs at the intersection of neuroscience and...
View ArticleTianeptine sodium milligram morphine equivalants (MME) estimate?
Thus far I have been unable to get a good estimate of tianeptine’s analgesic activity relative to other opioids. For practical clinical purposes this is often reckoned as milligram morphine...
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Thiaminorex RC stim.. be careful!
this compound a thiazoline the sulfur homolog of aminorex, an oxazoline: was discussed here on BL some time ago..apparently sold online by some stupid a..holes having no fckng idea WTF they doing. THIS...
View ArticleUnlocking the Brain: The Latest in Neuroscience and Pharmacology
Hello Neuroscience and Pharmacology Enthusiasts, I’m Serhat, and I'm thrilled to invite you to this fascinating journey into the world of neuroscience and pharmacology. This discussion, co-created with...
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Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug...
Opioids and Their Receptors The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their...
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